This article explores the impact of core self-evaluation on college students' sense of meaning in life. College students, being in early adulthood, face pressures and loneliness, often leading to a lack of meaning in life, which in turn affects their mental health. The article analyzes the importance of a sense of meaning in life and its relationship with core self-evaluation factors such as self-esteem, self-efficacy, locus of control, and neuroticism. By enhancing self-identity, cultivating positive personality traits, improving self-esteem, training positive rumination, and increasing clarity of self-concept, it is possible to effectively enhance college students' sense of meaning in life. Ultimately, creating a positive psychological environment helps college students better cope with life challenges and realize their personal value.